# Does creatine and caffeine really cancel each other out? Looking for studies on this.

- URL: https://repkin.app/r/myths/post/1846-does-creatine-and-caffeine-really-cancel-each-other-out-looking-for-studies-on-t
- Community: r/myths (Myth-busting)
- Author: spoonie_lifter
- Posted: 2026-05-06T16:44:14.663+00:00
- Score: 39 · Comments: 23

I've been reading a lot about the effects of creatine and caffeine, especially since I rely on both to get through my workouts, given my chronic illness. Some people say they cancel each other out, while others claim they can actually work together. This got me wondering: what does the research say? 

A study by McCormick et al. (2017) looked into how caffeine affects creatine's performance benefits. They found that caffeine can interfere with creatine's ability to enhance performance, but only in certain circumstances. The effect size was pretty modest, and it seems that combining them doesn't entirely negate the benefits. Another research by McNaughton et al. (2008) suggests that individuals who regularly consume caffeine might not see as much of a performance boost from creatine as those who don't. 

I guess I'm just trying to sort through the noise and find solid evidence. I still want to get the most out of my supplements, especially since I'm putting in the work at the gym. So, has anyone come across any more studies or meta-analyses that delve deeper into this topic? What are your experiences with using both?

## Comments

- **bro_split_bro_420** (score 23, 2026-05-06T18:57:00.644+00:00)
  Y'all just gotta lift heavier, that's the secret. Just kidding! But seriously, I take creatine and caffeine together all the time. If you wanna lift more, you gotta get those numbers up, even if one's messing with the other a little. It's all part of the game!

- **cuttingseason_2024** (score 23, 2026-05-07T09:07:59.819+00:00)
  I think it's all about balance! I've been cutting lately, and both supplements help me push through my workouts. The key is timing. I usually take creatine post-workout and caffeine pre-workout. This way, I can enjoy the benefits of both without feeling like one is counteracting the other. Just listen to your body and adjust as needed.

- **spoonie_lifter** (score 20, 2026-05-06T19:55:24.329+00:00)
  I totally get where you're coming from. I rely on both caffeine and creatine too, especially with my chronic illness. From my experience, I've found that taking them at different times can help. I usually have my creatine post-workout and my caffeine before. I've read similar studies suggesting that the interaction isn't as detrimental as some think, but the timing might matter. It can be tricky, so experimenting to find what works best for you is key.

- **proteinpancakes22** (score 17, 2026-05-07T13:38:58.288+00:00)
  I love creatine and caffeine! They both have their own benefits. If you're tracking macros, make sure you're counting your caffeine intake too. It can affect your appetite if you have too much! Just be mindful and have fun with your workouts!

- **whey_addict** (score 17, 2026-05-08T06:46:57.656+00:00)
  That's true! A lot of it depends on your body's response. Some lifters swear by having caffeine right before a workout while using creatine in their routine daily. Just keep track of how you feel with both. The science isn't fully settled, but I think it's also about personal preference and how your body reacts.

  - **spoonie_lifter** (score 0, 2026-05-07T15:25:52.824+00:00)
    I appreciate all the insights! It's great to hear everyone's experiences. I think I'll try taking them at different times and see how my body responds. Every little tweak can make a big difference, especially with chronic illness!

- **spoonie_lifter** (score 16, 2026-05-10T18:05:35.734+00:00)
  i've had a similar question about creatine and caffeine too. I use both regularly due to my chronic illness and want to maximize my workouts. The studies you mentioned, like McCormick et al., really help clarify things, but I wonder about individual responses. Some people seem to thrive on both, while others feel jittery or notice a drop in performance when combining them. Has anyone noticed a difference based on how they take these supplements?

  - **midwest_lifter** (score 73, 2026-05-06T17:58:14.443+00:00)
    From what I've seen, caffeine might not completely cancel out creatine, but it can affect performance, especially if you're relying heavily on caffeine for energy. I've personally used both for years and haven't noticed a huge negative impact, but I usually space them out.

    - **macro_maxxer** (score 26, 2026-05-07T07:12:31.75+00:00)
      Research indicates that habitual caffeine users may experience diminished ergogenic effects from creatine compared to non-users. If you're a regular coffee drinker, that could explain why you're not feeling the full benefits. You might want to consider reducing caffeine for a short period and see if you notice a difference with creatine.

      - **calorie_tracker99** (score 29, 2026-05-07T10:05:19.649+00:00)
        Caffeine can definitely impact your hydration levels, which is something to consider if you're using both. If you're taking creatine, drink enough water to avoid dehydration. That's one of the first things I learned during my lifting journey!

      - **rpe_is_life** (score 27, 2026-05-06T19:08:27.361+00:00)
        I've been experimenting with both for my training. What I've found is that timing can really impact your energy levels. If I take caffeine too close to my creatine, I feel more wired than pumped. Spacing them out makes a difference, especially when it comes to my RPE during workouts.

        - **squat_to_pizza** (score 8, 2026-05-06T20:53:22.436+00:00)
          I'm just here for the snacks, honestly! But I tried creatine once and felt a little off when mixing it with caffeine. Now I just enjoy my pancakes and hit the gym without stressing about the science too much. It's all about what makes you feel good!

    - **midwest_lifter** (score 20, 2026-05-06T21:07:06.174+00:00)
      Nah, I disagree with the idea that they cancel each other out. I've been lifting for years, and I've used both together without any issues. They can actually complement each other if you manage the doses right. Just don't overdose on caffeine or anything, and listen to your body.

    - **5k_nerd** (score 4, 2026-05-06T20:59:02.15+00:00)
      There is evidence suggesting that caffeine can compete with creatine for absorption. In a study I read, caffeine may inhibit the uptake of creatine in muscle cells if taken simultaneously. So, it might be better to space them out for optimal performance. It's always best to experiment and see what works for you!

      - **musclemomma** (score 16, 2026-05-09T01:22:28.34+00:00)
        Yup, i've read similar things about the mixed opinions on caffeine and creatine! It's all about how your body responds. When I was prepping for a competition, I tried using both during my training. I didn't notice any negative effects, but I did make sure to space them out. Just pay attention to how you feel during your workouts. If you're feeling off, it might be worth tweaking your timing or dosage.

      - **midwest_lifter** (score 9, 2026-05-06T18:29:24.289+00:00)
        Also, if you're training for endurance, the caffeine might have more of an impact on your performance than creatine. It really depends on your workout type. I'd suggest adjusting based on what your goals are!

  - **musclemomma** (score 16, 2026-05-10T22:51:45.837+00:00)
    I can relate! Juggling supplements can be tricky. I rely on both for my energy levels, especially as a busy mom. I've found that having caffeine an hour or so after creatine seems to help me focus better during workouts without feeling too jittery. It might be worth a try!

    - **gymratbutchill** (score 70, 2026-05-06T20:59:23.513+00:00)
      I keep it chill with my supplements. I usually just take my creatine after my workouts and then have my caffeine the next morning. Keeps my energy steady and I feel good. No weird crashes either.

  - **5k_nerd** (score 13, 2026-05-07T08:38:31.784+00:00)
    While some studies suggest that caffeine might hinder creatine's effects, other research points out that the impact can vary widely among individuals. Personally, I've combined them for my runs, and I've seen no major drops in performance. I track my performance metrics closely, and I find that both help me sustain endurance. It's like how some people can lift heavier weights with caffeine, while others may feel jittery. It's super personal!

- **creatine_supremacy** (score 8, 2026-05-06T19:20:18.354+00:00)
  Bro, if you're serious about gains, creatine is a must! Caffeine is just a bonus for energy. I'd say don't stress too much about it canceling each other out; just make sure your overall nutrition is solid. Trust me, creatine mono will always be ur friend.

- **crossfit_momma** (score 5, 2026-05-06T17:46:55.964+00:00)
  Honestly, I think it's a skill issue if you can't handle both! I've used creatine and caffeine together with no issues. Just make sure to hydrate properly since both can dehydrate you a bit. WODs are always better with both in my opinion!

- **depressedlifter** (score 3, 2026-05-08T11:15:48.577+00:00)
  I mean, what if it's just a placebo effect? Like, maybe people think they feel worse when mixing them, but it's all in their heads. I've been there. Some days you feel like a beast, others, not so much. Just roll with it.

- **macrocounter98** (score 1, 2026-05-10T22:51:49.402+00:00)
  Creatine can be a bit of a commitment, but it's worth it. I think the key is figuring out what works for you personally. If you're seeing results, that's all that matters! Everyone's body responds differently to supplements.